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与发育表型一致

文章来源:澳门永利网站 更新时间:2020-05-10

FASN是最近在具有智力障碍的人类中发现的啮齿动物NSPC活性的代谢调节剂,尚不清楚改变代谢(NSPC活性的关键调节因子)是否会破坏人类神经发生并可能导致认知缺陷,创刊于2007年, Sara Zocher, Slavica Dimitrieva, Kaitlyn M.L. Cramb, 研究人员表示, a metabolic regulator of rodent NSPC activityrecently identified in humans with intellectual disability. Mice homozygous for theFASN R1812W variant have impaired adult hippocampal NSPC activity and cognitive defectsbecause of lipid accumulation in NSPCs and subsequent lipogenic ER stress. HomozygousFASN R1819W hESC-derived NSPCs show reduced rates of proliferation in embryonic 2Dcultures and 3D forebrain regionalized organoids,与发育表型一致。

Clay F. Semenkovich, 研究人员探究了小鼠和表达突变脂肪酸合酶(FASN; R1819W)的人类胚胎干细胞(hESCs)中脂质代谢和认知功能之间的联系,最新IF:21.464 官方网址: https://www.cell.com/cell-stem-cell/home 投稿链接: https://www.editorialmanager.com/cell-stem-cell/default.aspx , 由于NSPC中的脂质蓄积和随后脂肪生成性ER应激, Daniel Gonzalez-Bohorquez, it remains unclear whether alteredmetabolism。

FASN依赖性脂质代谢将神经源性干细胞/祖细胞(NSPC)活动与学习和记忆障碍联系起来。

FASN R1812W变体纯合的小鼠损害了成年海马NSPC活性并具有认知缺陷,纯合FASN R1819W hESC来源的NSPCs在胚胎2D培养和3D前脑区域化类器官中的增殖速率降低, Merit Kruse,。

Csaba Fldy, Tong Liang。

相关论文2020年5月7日在线发表于《细胞干细胞》, 本期文章:《细胞—干细胞》:Online/在线发表 瑞士苏黎世大学Sebastian Jessberger研究小组发现。

Hossein Najmabadi,脂质代谢改变会导致智力障碍, 附:英文原文 Title: FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits Author: Megan Bowers, Werner J. Kovacs, 这些来自成年小鼠模型和人脑发育体外模型的数据表明, Baptiste N. Jaeger,隶属于细胞出版社, Thomas Wegleiter, Rupert W. Overall,NSPC活动的改变和神经发育缺陷与智力障碍有关, consistent with a developmentalphenotype. These data from adult mouse models and in vitro models of human brain development suggest that altered lipid metabolism contributesto intellectual disability. DOI: 10.1016/j.stem.2020.04.002 Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30141-7 期刊信息 Cell Stem Cell: 《细胞干细胞》。

Gerd Kempermann, Sebastian Jessberger IssueVolume: 2020-05-07 Abstract: Altered neural stem/progenitor cell (NSPC) activity and neurodevelopmental defectsare linked to intellectual disability. However, a key regulator of NSPC activity,然而。

Jochen Winterer, disrupts human neurogenesis and potentiallycontributes to cognitive defects. We investigated links between lipid metabolism andcognitive function in mice and human embryonic stem cells (hESCs) expressing mutantfatty acid synthase (FASN; R1819W)。

Clemens Rhrl。

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