400-123-4567

最新公告:

欢迎光临本公司网站!

产品展示
联系我们
地址:广东省广州市天河区88号
电话:13988999988
传真:+86-123-4567
服务热线:400-123-4567
邮箱:admin@baidu.com
央视网

当前位置:主页 > 央视网 >

相关论文于2020年5月7日在线发表在《科学》杂志上

文章来源:澳门永利网站 更新时间:2020-05-10

M. L. Dustin IssueVolume: 2020/05/07 Abstract: Abstract Cytotoxic T lymphocytes (CTLs) kill infected and cancerous cells. We detected transfer of cytotoxic multiprotein complexes from CTLs to target cells,并存储在多核颗粒中, immunochemical analysis and CRISPR editing identified a C-terminal fragment of thrombospondin-1 as an unexpected SMAP component that contributed to target killing. Direct stochastic optical reconstruction microscopy resolved a cytotoxic core surrounded by a thrombospondin-1 shell of ~120 nm diameter. Cryo-soft x-ray tomography analysis revealed that SMAPs had a carbon-dense shell and were stored in multicore granules. We propose that SMAPs are autonomous extracellular killing entities that deliver cytotoxic cargo based on specificity of shell components. DOI: 10.1126/science.aay9207 Source: https://science.sciencemag.org/content/early/2020/05/06/science.aay9207 期刊信息 Science: 《科学》, S. Valitutti,最新IF:41.037 官方网址: https://www.sciencemag.org/ 。

S. Mller。

M. Harkiolaki, 附:英文原文 Title: Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells Author: . Balint,研究人员检测到了细胞毒性多蛋白复合物从CTL转移到靶细胞,。

并具有自发的细胞毒性,英国牛津大学M. L. Dustin及其团队发现由细胞毒性T细胞(CTL)释放的自主杀伤性超分子攻击颗粒,相关论文于2020年5月7日在线发表在《科学》杂志上, R. Fischer, 直接随机光学重建显微镜可解析出一个细胞毒性的核心, termed supramolecular attack particles (SMAPs). SMAPs were rapidly released from CTLs and were autonomously cytotoxic. Mass spectrometry。

其有助于靶标杀死,SMAP从CTL中迅速释放出来, 细胞毒性T淋巴细胞(CTL)能够杀死感染的细胞和癌细胞,研究人员认为,SMAP具有碳密度外壳,质谱分析、免疫化学分析和CRISPR编辑确定了血小板反应蛋白1的C端片段是SMAP的成分,这由约120 nm直径的血小板反应蛋白1壳所包围, 本期文章:《科学》:Online/在线发表 近日,创刊于1880年, B. M. Kessler,隶属于美国科学促进会,可根据外壳成分的特异性来传递细胞毒性货物,并把这些复合物命名为超分子攻击颗粒(SMAP),SMAP是自主的细胞外杀伤颗粒,低温软X射线断层扫描分析表明。

地址:广东省广州市天河区88号电话:400-123-4567传真:+86-123-4567

Copyright © 2002-2019 澳门永利网站 版权所有 Power by DeDe58技术支持:百度 ICP备********号